Diet & Nutrition - Nutrition Supplements

Multivitamin/mineral Supplements

August 2022

Diet & Nutrition - Nutrition Supplements

Multivitamin/mineral Supplements

August 2022

What is multivitamin/mineral (MVM) dietary supplements?

Multivitamin/mineral (MVM) supplements contain a combination of vitamins and minerals, and sometimes other ingredients as well. People refer to them by many names, including multis and multiples or simply vitamins. Each of the vitamins and minerals in MVMs have a unique role in the body. For more information about each one, see our individual vitamin and mineral fact sheets.

MVMs cannot take the place of eating a variety of foods that are important to a healthy diet. Foods provide more than vitamins and minerals. They also have fiber and other ingredients that may benefit health.

What kinds of MVM supplements are available?

Many types of MVMs are available in stores and online. Companies choose which vitamins and minerals—and how much—to include in their products. There isn’t a standard MVM or a standard list of ingredients.

Among the most common MVMs are basic, once-daily products that contain all or most vitamins and minerals in amounts close to what is recommended.

Some MVMs contain higher-than-recommended amounts of some vitamins and minerals. These products may come in packs of two or more pills to take each day.

Manufacturers promote some MVMs for specific purposes, such as better athletic performance or energy, weight control, improved immunity, or eye health. These products often contain herbal and other ingredients (such as green tea, coenzyme Q10, probiotics, or glucosamine) in addition to vitamins and minerals.

The recommended amounts of nutrients vary by age and sex and are known as Recommended Dietary Allowances (RDAs) and Adequate Intakes (AIs). However, supplement labels use the Daily Value (DV) for each nutrient, which is often, but not always, similar to the RDA or AI for that nutrient. The %DV for each nutrient will show you how much (what percentage) a serving of the product contributes to reaching the DV.

What are some effects of MVMs on health?

Here are some examples of what research has shown about taking MVMs to increase nutrient intakes, improve health, and reduce the risk of disease.

Increase nutrient intakes

Taking an MVM increases the amounts of nutrients you get each day. This can help you get recommended amounts of vitamins and minerals when you cannot or do not get enough of them from food alone. But taking an MVM can also raise the chances of getting too much of some nutrients, such as iron, vitamin A, zinc, niacin, and folic acid, especially if you take a product that contains more than the recommended amounts of some nutrients. For information about recommended amounts, see our individual vitamin and mineral fact sheets.

Some people take an MVM as a form of dietary or nutritional insurance. Yet people who take MVMs often consume more vitamins and minerals from food and beverages than those who don’t.

Health promotion and chronic disease prevention

It is difficult to determine whether MVMs provide health benefits because studies often use different products, making it hard to compare their results. Also, many MVMs are available, and manufacturers can change their composition at will, so it’s hard for researchers to study whether specific combinations of vitamins and minerals affect health. Also, people with healthier diets and lifestyles are more likely to take MVMs, making it hard to identify any benefits from the products alone.

Scientists have studied whether taking MVMs affects the risk of health problems and diseases such as cancer, heart disease, osteoporosis, lung disorders, psychiatric disorders, and the risk of death. Most studies have found that taking MVMs has little or no effect on these health outcomes.


Overall, it’s unclear whether taking an MVM affects cancer risk.

One large study found that male physicians aged 50 and older who took a basic MVM for about 11 years had a slightly reduced risk of developing cancer—but not of dying of the disease—compared with those who took a placebo. In another large study in men and women ages 60–65 years and older, those who took a basic MVM for about 3.6 years did not have a lower risk of developing cancer, except for lung cancer. Other studies found conflicting evidence. For example, various studies have found that MVMs might increase, decrease, or not affect the risk of breast cancer in women. Some studies suggest MVMs might reduce the risk of colon cancer, but increase the risk of prostate cancer, lung cancer, and leukemia in men.

Cardiovascular disease (CVD)

Overall, MVMs appear to have little or no effect on the risk of CVD.

Most studies in men and women comparing MVMs to a placebo have found that the MVMs do not reduce the risk of CVD, including heart attacks or strokes or resulting deaths. Most other studies of people who take MVMs on their own have found that these products do not protect against CVD either.

Cataracts and age-related macular degeneration (AMD)

A specific combination of vitamins and minerals can slow down vision loss from AMD, an eye disease that can blur your central vision.

The Age-Related Eye Disease Study (AREDS) showed that people with AMD and/or cataracts who took a daily supplement of high-dose vitamin C (500 mg), vitamin E (400 IU), beta-carotene (15 mg), zinc (80 mg), and copper (2 mg) for about 6 years had a lower chance of developing advanced AMD. They also had less vision loss than those who did not take the supplement. However, the supplements did not reduce the risk of getting AMD or the risk of cataracts. A later study showed that the supplement was equally effective without beta-carotene.

Pregnancy and birth outcomes

Prenatal MVM supplements can help a pregnant person get enough nutrients, especially key nutrients such as folic acid and iron. Pregnant people who are at risk of malnutrition might be less likely to have a baby that is premature or has a low birth weight or small size if they take an MVM during pregnancy. But for pregnant people who already get enough of all nutrients, MVMs might not make any difference.

Other outcomes

Several studies have examined the link between MVM use and conditions such as osteoporosis, lung diseases, psychiatric disorders, and even risk of death. Most found that MVMs have no effect on these health outcomes.

MVMs and healthful eating

People should get most of their nutrients from food and beverages, according to the federal government’s Dietary Guidelines for Americans. Foods contain vitamins, minerals, dietary fiber, and other components that benefit health. In some cases, fortified foods and dietary supplements are useful when it is not possible to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy).